DIVERGENT METABOLISM BETWEEN TRYPANOSOMA CONGOLENSE AND TRYPANOSOMA BRUCEI RESULTS IN DIFFERENTIAL SENSITIVITY TO METABOLIC INHIBITION.

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense.In comparison to the well-studied T.brucei, there is a major paucity of knowledge regarding the biology of T.congolense.Here, we use a combination of omics technologies

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Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.

Inhibitory glycinergic neurotransmission is terminated by sodium and chloride-dependent plasma membrane glycine transporters (GlyTs).The mainly glial glycine transporter GlyT1 is primarily responsible for the completion of inhibitory neurotransmission and the neuronal glycine transporter GlyT2 mediates the reuptake of the neurotransmitter that is u

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